Syndrome of inappropriate antidiuresis in doxylamine overdose

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Nephrogenic syndrome of inappropriate antidiuresis.

The nephrogenic syndrome of inappropriate antidiuresis (NSIAD) is a rare, recently recognized disorder in water balance affecting not only infants but also adults. A new molecular mechanism responsible for NSIAD has recently been identified: a gain of function of the arginine vasopressin (AVP) receptor type 2 (V2R), causing the constitutive activation of the receptor. Clinical presentation and ...

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The Syndrome of Inappropriate Antidiuresis

From the Division of Nephrology and Hypertension and the Department of Physiology and Pharmacology, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR (D.H.E.); and the Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver (T.B.). Address reprint requests to Dr. Ellison at the Division of Nephrology and Hypertensio...

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The syndrome of inappropriate antidiuresis.

From the Division of Nephrology and Hypertension and the Department of Physiology and Pharmacology, Oregon Health and Science University and Veterans Affairs Medical Center, Portland, OR (D.H.E.); and the Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver (T.B.). Address reprint requests to Dr. Ellison at the Division of Nephrology and Hypertensio...

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Nephrogenic Syndrome of Inappropriate Antidiuresis

Mutations in the vasopressin V2 receptor gene are responsible for two human tubular disorders: X-linked congenital nephrogenic diabetes insipidus, due to a loss of function of the mutant V2 receptor, and the nephrogenic syndrome of inappropriate antidiuresis, due to a constitutive activation of the mutant V2 receptor. This latter recently described disease may be diagnosed from infancy to adult...

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Transient nephrogenic syndrome of inappropriate antidiuresis

The patient is a 56-year-old man who entered the hospital because of hyponatraemia. He observed problems with short-term memory, gait disturbances, and had fallen while going downstairs. He also claimed attention deficits and visual disturbances. He had been presented to his primary care physician who observed a low serum Na (102 mmol/L) and referred him for further diagnostic studies. The pati...

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ژورنال

عنوان ژورنال: Case Reports

سال: 2012

ISSN: 1757-790X

DOI: 10.1136/bcr-2012-007428